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宾夕法尼亚大学回避直接祝贺卡塔琳·卡里科获得诺贝尔医学大奖，因为校方曾将她降级、削减工资，甚至强迫她离开实验室。然而，宾夕法尼亚大学却通过她的专利授权获取了数百万美元收入。 事实上，直到今天，在学校曾经一起工作过的同事仍然不那么喜欢她、甚至鄙视她——卡塔琳·卡里科，2023年诺贝尔医学奖得主。 究竟为什么？有哪些难以释怀的恩怨或纠结呢？看看《华尔街日报》原文报道： 诺奖得主 Karikó和Drew 在媒体见面会上 阅读文摘 2021年8月，匈牙利首都布达佩斯大街上竖起一幅壁画，庆祝科学家卡塔琳·卡里科的卓越工作和贡献——抗击新冠疫情。 After , of Her Nobel Prize that once Karikó and cut her pay has made of from her work. The of is in the glow of two who this week were the Nobel Prize in for their work on RNA. Until , the and its one of those . Penn Karikó, her to a lab on the of while her pay. Karikó’s her mRNA and some ’t work with her, to her and at the . , Karikó Penn , Drew , to work with her on mRNA for and drugs, most at the , other . Karikó hasn’t only her wrong but also the of . Her with lead to the mRNA that the Covid-19 and now shows for flu, and other . Penn, which their mRNA , has made of from that it. And on , when Karikó and were the Nobel, on top of in years, the a on their work. The a of the , world of and , where is a , is a and those with or can to gain and . “It’s a ,” said David , who is chair of at Lenox Hill , spent 18 years and at Penn and was Karikó’s and . Penn wasn’t the only to doubt Karikó’s in mRNA when many other a gene-based . In a of how her ideas were at the time, she had her and big — for those to get ahead in and gain . her with the : Karikó could . In , she often was the first to point out in their work. Karikó didn’t to , she just felt the need to call out , she later said. Once, she saw that cells two had on for weeks had and were no and them for , her . “This is trash,” Karikó told them. The Karikó and Penn over many years. A of , she came to the in 1989 as a in the of the . Her job, which wasn’t a -track , was to do and for . Karikó was at the to her mRNA and a in the , to the that she with . Yet Karikó also was to . Once, while with at a party, a that Karikó was for him on a . “You think I’m for you?” Karikó asked him, livid, to who the . “I’m here to , I’m never, ever, for you.” - were -born —some to them as “the ”— to for the of in the Ivy ’s world-class labs and Penn to their green-card . Karikó felt like of a -class . Once, she was for using water to a of her lab, than climb five of to get some from a , she later . After long days in the lab, Karikó home to write grant , to use mRNA to . She found . her , her title at the . Penn and had good for their . Most else was with using DNA, a . DNA has two of that wind each other like a , it . By , mRNA is - and and hard to work with. had to wear just to touch in with the ; just on the made them for mRNA. the cell, mRNA only a short while it is . And the body has to ward off the . To Karikó, mRNA was the —it only to get the cell’s walls to , not all the way into the , like DNA. Karikó’s grant met and she had to rely on to pay her . In 1995, after Karikó 40, she an : Leave Penn or agree to a . Karikó a new, lower-paid . It left her , she later said, while her time to keep her mRNA . “It’s like Fight Club, when you lose you are ,” she said in an in 2020 for the book “A Shot to Save the World.” Then she and a . They the base , or , of mRNA, to avert an . Now, the could get into cells to ample , the key to and drugs. Penn their mRNA . Karikó and tried to it for their but ’t the price the , . Penn it to . Over the past few years, Penn made tens of of the to Today, Karikó is an in the ’s of . “ Karikó and Drew are who the of and ,” Penn’s , Liz , said this week. Added Penn’s of media , Ron Ozio, in a : “We and are for the Dr. has made to and to Penn her time with the .” Some other out the for its of Karikó. “UPenn needs to to Nobel Prize 2023 Dr. Karikó,” said and Eric Feigl-Ding on X, known as . added: “Didn’t you fire ? Just ……” Does Penn’s of Karikó with how is and ? Join the below. by Penn and to Karikó’s work how works, said. Her with was a risky bet. It took them years to their mRNA and there was a good their would prove . “It begs the of how many aren’t being for their work,” said. At the same time, are in most every field. “ was third, Tom Brady was 199th, you can say ‘how did miss them’, too,” said. “The story is that she .” By @WSJ 你可能还喜欢 在复印机旁的一次偶遇，由此产生了mRNA技术拯救了数百万人的生命 她设想用mRNA制造可以替代药物的治疗性蛋白质：“几十年前，当我开始这项工作时，我列出了30种我认为RNA可能治疗的疾病，现在仍有25种。” 关注我们，获取生物医学前沿最新资讯 |